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Risks and Benefits of Hormonal Therapy for Men

In the human body, testosterone is essential. Its effects boost libido and hormone balance function, induce hematopoietic, and increase muscle and bone strength and density. Age-related declines in testicular testosterone production can cause its positive effects to be lessened. Men with low testosterone levels have been treated with testosterone replacement therapy (TRT), but what are the advantages and are there any drawbacks?

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Testosterone Replacement Therapy: What Is It?

The United States Food and Drug Administration has approved testosterone replacement therapy (TRT) as a treatment option for men who are either testosterone deficient or have low testosterone levels in addition to a related medical condition. One such condition requiring the use of TRT is late-onset hypogonadism (LOH), whose prevalence has grown recently as a result of an ageing population. A clinical and biochemical syndrome known as late-onset hypogonadism is characterized by a decline in the amount of serum testosterone the testes produce. An increase in body fat, a depressed or low mood, a decline in libido, a loss of muscle mass and strength, and a reduction in bone density are just a few of the symptoms that men with LOH may experience.

Heart Health

 According to research, testosterone levels and the onset of cardiovascular disease are related. A 17-year longitudinal study of 3,518 men found that men with low serum testosterone levels had a twofold increased risk of dying from cardiovascular disease compared to men with normal or anticipated serum testosterone levels. In later studies, it was discovered that higher levels of testosterone were associated with favorable cardiovascular health profiles in middle-aged patients, including higher levels of high-density lipoprotein cholesterol and lower levels of insulin, systolic blood pressure, and triglycerides.

Significantly larger mass of muscle

Loss of muscle mass and strength, which can impair mobility, is one of the well-studied negative effects of low serum testosterone. TRT administration was able to partially undo some of the effects mentioned above, according to research examining the effects of TRT in a group of hypogonadal men. Overall lean body mass improved as a result of an increase in muscle mass and lipid oxidation. Many patients, especially those with limited mobility, reported that these effects improved their quality of life.